When using Microsoft SQL Server Import and Export Wizard you might get this error when attempting to import an XLSX file:
TITLE: SQL Server Import and Export Wizard
The operation could not be completed.
The 'Microsoft.ACE.OLEDB.12.0' provider is not registered on the local machine. (System.Data)
This is because the default wizard is launches the 32 bit version.
Simply open the 64 but version from the Start menu (search “import”)